About The Company
SILENCE DISEASE. AMPLIFY LIFE.™
Alnylam is a leading independent biopharmaceutical company and the pioneer in RNA interference (RNAi) therapeutics – a revolutionary approach to treating diseases which “silences” the genes that cause or contribute to them.
Founded in 2002 by a group of distinguished researchers and biotech leaders, Alnylam’s work over more than two decades has yielded the critical breakthroughs and advancements that have made the field of (RNAi) therapeutics possible. In 2018, our first commercial medicine, and the world’s first RNAi therapeutic was approved. Since then, four more Alnylam-developed medicines have been approved and we’re hard at work developing new therapies to treat both rare and prevalent diseases.
We are a global and diverse company of 2,500+ people. We pride ourselves on fostering a fun, inclusive and dynamic work environment where employees can recognize their fullest potential. That's why we’re consistently ranked as a top employer by The Boston Globe (2015-24), Science Magazine (2018-25), Fast Company (Best Workplaces for Innovators 2020-25) and LinkedIn (2024).
We are based in Cambridge, Massachusetts (U.S.), with offices throughout North America, Europe, Asia, and South America.
See our social media community guidelines: https://bit.ly/2FcRhJy.
Please note: If you wish to report an adverse event or product complaint, please email medinfo@alnylam.com or you may call us using the following telephone numbers: for North America, 877.ALNYLAM (877.256.9526), for Europe, +31 20 369 7861
Fraudulent Recruitment Activity
Be aware of the potential for scams and fraudulent recruitment activity from individuals claiming to represent Alnylam Pharmaceuticals. Alnylam never conducts its interview process via messaging apps, freelance sites, or social media platforms. Alnylam team members only communicate with potential candidates through an official Alnylam email address ending in “@alnylam.com.”
About the Role
Design plasmid contructs for generating cell lines stably expressing membrane proteins Organize and maintain a functional inventory of plasmid sequences Establish tools, execute assays, and develop in vitro models to evaluate delivery and activity of siRNA conjugates Work collaboratively across the organization to optimize RNA drugs for tissue-specific delivery Design controlled experiments, analyze data, and present findings to various groups across the research organization PhD in biochemistry, molecular biology, or a related field with up to 3 years of work experience in an industry setting Experience in the design and optimization of plasmids for efficient cellular expression of membrane proteins is required Expertise with mammalian cell culture including general maintenance, transfection and transduction, imaging techniques, and cell line generation is required Experience with standard biochemical and cell-based assays for assessing receptor/ligand interactions (flow cytometry, microscopy, ELISA, BLI) is strongly preferred Experience with plasmid registration and inventory maintenance is preferred Strong interpersonal skills and excellent communication skills (written and oral) are required
Key Skills
Plasmid DesignCell CultureTransfectionTransductionImaging TechniquesCell Line GenerationBiochemical AssaysCell-Based AssaysFlow CytometryMicroscopyELISABLIData AnalysisCommunication SkillsInterpersonal Skills
Categories
Science & ResearchHealthcareTechnology