Protein Scientist, Downstream Process Development

We are looking for a talented scientist to lead the development, optimization, and scale-up of downstream purification processes for monoclonal antibodies and other biologics, from early development through clinical and commercial manufacturing. This role is responsible for designing robust, scalable, and regulatory-compliant purification processes, with a focus on translating lab-scale workflows into high-yield, cost-effective GMP manufacturing processes. The individual will serve as a technical leader across process development, tech transfer, and manufacturing.

 Key Responsibilities:

• Design, develop, and optimize downstream purification processes for monoclonal antibodies and other therapeutic and non-therapeutic proteins, including clarification, capture, intermediate, and polishing steps
• Lead scale-up activities from bench to pilot and commercial manufacturing, including process modeling and tech transfer to CDMOs.
• Author and review technical reports, development protocols, and regulatory documentation, in support of tech transfer
• Lead or support technology transfer to GMP manufacturing sites
• Collaborate with upstream, analytical, and quality teams to ensure process robustness and product quality
• Support process validation activities
• Evaluate and implement new purification technologies to improve efficiency, yield, and cost of goods

• 5+ years of industry experience in downstream process development for monoclonal antibodies or closely related biologics
• Ph.D. in biochemical engineering, chemical engineering, biochemistry, or related field; or equivalent industry experience 
• Demonstrated experience scaling purification processes from bench scale to pilot and/or commercial manufacturing scale
• Deep expertise in core mAb purification unit operations:
• Protein A affinity chromatography
• Ion exchange (IEX), hydrophobic interaction chromatography (HIC)
• Viral inactivation and viral filtration
• Ultrafiltration/diafiltration (UF/DF)
• Expertise in chromatography process development and scale-up, including mass transfer and capacity studies, Design of Experiments (DoE) screening for performance optimization, as well as productivity and resin lifecycle modeling
• Hands-on experience with manufacturing-relevant equipment (ÄKTA process systems, large-scale columns, TFF systems)
• Demonstrable success in tech transfer to GMP manufacturing environments (internal or CDMO)
• Experience managing external partners (CDMOs) and overseeing manufacturing campaigns
• Experience overseeing manufacturing campaigns, including managing timelines, risk, and troubleshooting efforts to support tech transfer 
• Appetite for fast-paced startup environment and teamwork

Compensation: base salary is expected to be $130-170K depending on experience, with additional bonus compensation, equity compensation, and benefits.